TIGOR is a cross-university institute at Tufts to advance obesity science for reducing the prevalence of obesity in national and international populations. Obesity presents an unprecedented global crisis. It is not only a cause of premature death and serious health problems, including diabetes, cardiovascular disease, and stroke, but also an underlying driver of an even broader set of societal problems such as high rates of disability, inefficiency and absenteeism in the workforce, rising health care costs, stigmatization, and bullying. Obesity continues to disproportionately affect certain racial and ethnic groups—particularly Black Americans and Hispanics/Latinos—and individuals with low socioeconomic positions. Research directed towards supporting improvements in obesity prevention and treatment is urgently needed. TIGOR faculty conduct cutting-edge research to inform and scale effective interventions to reduce obesity in the US and worldwide. Our work will advance health equity for all and provide outstanding training for the next generation of researchers. Our team consists of over 40 faculty members along with graduate students from across Tufts University and Tufts Medical Center.